About

I’m currently a Systems Pharmacology Expert at LYO-X GmbH where I combine pharmacological principles and statistical rigor in population PK/PD modeling with mechanism-based approaches required for extrapolation to support decision making at critical development points and for regulatory interaction.

Work Experience

2019-now - Systems Pharmacology Export @ LYO-X GmbH, Allschwil, Switzerland

  • Topic: Development of semi-mechanistic models of drug pharmacokinetics and pharmacodynamics to support decision making at critical development points and for regulatory interaction.

2016-2019 - Postdoctoral Research Fellow @ Division of Systems Biomedicine & Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands

  • Topic: Application of engineering methods to systems pharmacology models to study the effects of drug dosing frequencies on drug effects.
  • Supervisors: Prof. Dr. P. H. van der Graaf, Dr. J. Yates, Prof. Dr. V. Rottschäfer, Dr. T. Post

2009 - Internship @ Computational Systems Biology Group, Bayer Technology Services GmbH, Leverkusen, Germany

  • Topic: Implementation and analysis of a complex mathematical model of the photosynthesis mechanism in C3-plants
  • Supervisors: Dr. J. Lippert, Dr. L. Küpfer, Dr. T. Eissing

2007 - Internship @ Insilico Biotechnology AG, Stuttgart, Germany

  • Topic: Modeling of the mitochondrial respiratory chain with focus on biological feasibility by the incorporation and maintenance of publicly available databases.
  • Supervisor: K. Mauch

2005-2006 - Internship @ Systems and Control Group, TAO Technologies GmbH, Stuttgart, Germany

  • Topic: Development of software tests and simulations to analyze and optimize real-time hardware for components in autonomic aircrafts.
  • Supervisor: Prof. Dr. B. Kröplin

Publications

Schulthess P. , Rottschäfer V. , Yates J. W. T. & van der Graaf P. H. Optimization of cancer treatment in the frequency domain. AAPS J, 21:106 2019 • doipdf

Schulthess P., van Wijk R. C., Krekels E. H. J., Yates J. W. T., Spaink H. P. & van der Graaf P. H. Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies. CPT Pharmacometrics & Systems Pharmacology, 7:285-287, 2018 • doipdf

Schulthess P., Post T. M., Yates J. & van der Graaf P. H. Frequency-Domain Response Analysis for Quantitative Systems Pharmacology Models. CPT Pharmacometrics & Systems Pharmacology, 7:111–123, 2017 • doipdf

Schulthess, P., Löffler A., Vetter S., Kreft L., Schwarz M., Braeuning A., Blüthgen N. Signal Integration by the CYP1A1 Promoter - A Quantitative Study. Nucleic Acids Research, 43:5318–5330, 2015 • doipdf

Thomas P., Durek P., Solt I., Klinger B., Witzel F., Schulthess P. , Mayer Y., Tikk D., Blüthgen N., Leser U. Computer-assisted curation of a human regulatory core network from the biological literature. Bioinformatics, 15;31(8):1258-66, 2015 • doipdf

Schulthess, P. and Blüthgen, N. From Reaction Networks to Information Flows - Using Modular Response Analysis to Track Information in Signaling Networks. Methods in Enzymology, 500:397-409, 2011 • doipdf

Talks

11/2018 - Frequency-domain derived optimisation of treatment modalities for three tumour growth models @ Pharmacokinetics UK (PKUK), Manchester, United Kingdom • pdf

09/2016 - Frequency-domain response analysis for quantitative systems pharmacology models @ Conference on Complex Systems, Amsterdam, The Netherlands • pdf

03/2016 - Thermodynamic modeling explains the regulation of CYP1A1 expression in the liver Ph.D. Defense @ Institude for Theoretical Biology, Humboldt University Berlin, Berlin, Germany • pdf

03/2013 - Binding Site Cooperativity and Dual Signal Integration in CYP1A1 Induction @ 79th Annual Conference of the German Society for experimental and clinical Pharmacology and Toxicology, Halle (Saale), Germany • pdf

07/2012 - Cooperativity between Aryl Hydrocarbon Receptor and β-catenin Binding Sites in Hepatocytes @ 4th Conference on Systems Biology of Mammalian Cells, Leipzig, Germany • pdf

10/2010 - From Reaction Networks to Information Flow – Using Modular Response Analysis to Track Information in Signaling Networks @ 11th International Conference on Systems Biology, Edinburgh, Scotland • pdf

Posters

05/2018 - Frequency-domain derived optimisation of cell-cycle specific cancer treatment @ 27th Page Meeting, Montreux, Switzerland • pdf

06/2017 - Frequency-domain response analysis for quantitative systems pharmacology models @ 26th Page Meeting, Budapest, Hungary • pdf

07/2015 - Signal Integration by the CYP1A1 Promoter — A Quantitative Study @ 40th FEBS Congress, Berlin, Germany • pdf

05/2014 - Cooperativity between Aryl Hydrocarbon Receptor and β-catenin binding sites in CYP1A1 Induction @ 5th Conference on Systems Biology of Mammalian Cells, Berlin, Germany • pdf

10/2010 - From Reaction Networks to Information Flow – Using Modular Response Analysis to Track Information in Signaling Networks @ 11th International Conference on Systems Biology, Edinburgh, Scotland • pdf

Teaching

2017-2019 - Lecturer in Quantitative Pharmacology, Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Center for Drug Research, Leiden University, The Netherlands

2015-2016 - Teaching assistant in Farmacologie, Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Center for Drug Research, Leiden University, The Netherlands

2010-2012 - Teaching assistant in Data analysis and numerical methods, Institute for Theoretical Biology, Humboldt University of Berlin, Germany

Education

2009-2016 - PhD in Theoretical Biophysics, Charité - Universitätsmedizin Berlin, Germany

  • PhD Thesis: Thermodynamic modeling explains the regulation of CYP1A1 expression in the liver • doi
  • Supervisors: Prof. Dr. N. Blüthgen, Computational Modeling in Medicine, Institute for Pathology, Charité – Universitätsmedizin Berlin, Germany

2002-2009 - Diploma in Engineering Cybernetics, University of Stuttgart, Germany

  • Diploma Thesis: Layer-based modeling of EGF Receptor Signaling and Thermodynamic Feasibility Analysis
  • Supervisors: Prof. O. Sawodny, Dr. M. Koschorreck, Institute for System Dynamics, University of Stuttgart, Germany

2006-2007 - Study of Systems Biology, University of Barcelona, Spain

  • Student Thesis: Modeling and Simulation of the Mitochondrial Electron Transport Chain
  • Supervisors: Dr. M. Cascante, Dr. V. Selivanov, Integrative Biochemistry and Cancer Therapy, University of Barcelona, Spain

Scholarships & Awards

2015 - PhD Scholarship, Charité - Universitätsmedizin Berlin

2010 - GENESYS Travel Award, 11th International Conference on Systems Biology, Edinburgh, Scotland